HSEGHMM: HIDDEN MARKOV MODEL-BASED ALLELE-SPECIFIC COPY NUMBER ALTERATION ANALYSIS ACCOUNTING FOR HYPERSEGMENTATION

hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation

Abstract Background Somatic copy number alternation (SCNA) is a common Front Grill feature of the cancer genome and is associated with cancer etiology and prognosis.The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and the tumor purity.Next generation sequ

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The Display Behavior of Sub-Adult Greater Bird-of-Paradise (Paradisaea apoda): A Learning Process from an Adult?

The Greater Bird-of-Paradise (Paradisaea apoda) is a bird that performs a courtship display (lekking) to attract females during the mating season.The objective of this study was to examine the display behavior of adult and sub-adult males on lek trees as a learning process by a sub-adult and identify the lek trees.The research was conducted in the

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Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance

Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases.The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to be Quality Warranty For Extra 90 Days mediated largely by its prominent stroma, which is supported b

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